|Acronym : ZikAlliance||A global Alliance for Zika Virus control and prevention.|
|Principal investigator||X. de Lamballerie (Inserm)|
|IPNC main investigator||M. Dupont-Rouzeyrol|
|IPNC collaborators||N. Pocquet, O. O’Connor, M. Minier|
|Other collaborators||AB. Failloux (IP), ZikAlliance consortium, task 6.2|
|Project total budget||11.9M€||Budget devoted to IPNC:||30 000 €|
|Timeline||Start date: Jan. 2017||End date: December 2019|
|In 2014, Zika (ZIKV) emerged in the Pacific region and spread in the world. In early 2016, WHO declared the ZIKV outbreak an international public health emergency in connection with the severe neurological consequences observed following ZIKV infection. The ZikAlliance project is a large project that aims to study ZIKV and its consequences at different scales and across different environments. IPNC is a partner of this project and is involved in the WP6: Vectors and Vector control and more particularly the vector competence part. The objectives presented here correspond only to the task in which IPNC is a partner.|
|Evaluate the vector competence of several mosquitoes species and populations from different environments (American Asia, Africa…) against several ZIKV lineage|
|Homogenization of protocols.
Generation of F1 populations of Aedes aegypti and Culex quinquefasciatus from New Caledonia.
Production of Zika virus stocks, different lineages.
Vector competence experiments: measurement of infection, dissemination and transmission parameters.
Analysis of the results at the global scale.
|Two populations of Ae. aegypti (Nouméa and Koné) were generated. The ZIKV African lineage and Asian / American lineage were received. Experimental infections are scheduled for the first half of 2018.|
|Mieux connaître la capacité de transmission des différents vecteurs pour les différentes lignées est nécessaire à l’évaluation du risque et à la mise en place de méthodes de lutte et de prévention plus ciblées et plus performantes.|
|Publications : Dupont-Rouzeyrol et al, In press, Calvez et al, submitted ; Boyer et al, submitted; Simon et al, submitted ; Calvez et al, in prep.|