Publications UREL


Leptospira and leptospirosis
Goarant C, Trueba G, Bierque E, Thibeaux R, Davis B, De la Peña Moctezuma A

In: J.B. Rose and B. Jiménez-Cisneros, (eds) Global Water Pathogen Project. ( A. Pruden, N. Ashbolt and J. Miller (eds) Part 3 Bacteria) Michigan State University, E. Lansing, MI, UNESCO.

Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics
Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, Ismail N, Mohd Khalid MK, Amran F, Masuzawa T, Nakao R, Amara Khorba A, Bourhy P, Veyrier FJ, Picardeau M
PLoS Negl Trop Dis 13(5):e0007270. Texte intégral/Full text Format pdf

Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect
Goarant C, Picardeau M, Morand S, K Marie McIntyre
J Glob Health 9(1):010302. Texte intégral/Full text Format pdf


Leptospirosis in French historical medical literature – Weil’s disease or Kelsch’s disease?
Tarantola A, Goarant C. 
Am J Trop Med Hyg 99(6):1366-1368. doi: 10.4269/ajtmh.18-0629. Vers PubMed

A large leptospirosis outbreak following successive severe floods in Fiji, 2012.
Togami E, Kama M, Goarant C, Craig SB, Lau C, Ritter JM, Imrie A, Ko A, Nilles E. 
Am J Trop Med Hyg 99(4):849-851. doi: 10.4269/ajtmh.18-0335. Vers PubMed

Evidence of human leptospirosis cases in a cohort of febrile patients in Bangui, Central African Republic: a retrospective study, 2012-2015.
Rubbo PA, Soupé-Gilbert ME, Golongba DM, Mbombo F, Girault D, Nakoune E, Lombart JP, Breurec S, Goarant C. 
BMC Infect Dis 18(1):376. doi: 10.1186/s12879-018-3298-z. Texte intégral/Full text

High incidence of leptospirosis in an observational study of hospital outpatients in Vanuatu highlights the need for improved awareness and diagnostic capacities.
Pakoa JG, Soupé-Gilbert ME, Girault D, Takau D, Gaviga J, Gourinat AC, Tarantola A, Goarant C. 
PLoS Negl Trop Dis 12(6):e0006564. doi: 10.1371/journal.pntd.0006564. Texte intégral/Full text

A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity.
Guernier V, Goarant C, Benshop J, Lau CL.
PLoS Negl Trop Dis 2018 ; 12:e0006503. doi: 10.1371/
journal.pntd.0006503. Texte intégral

Biodiversity of environmental Leptospira: improving identification and revisiting the diagnosis.
Thibeaux R, Girault D, Bierque E, Soupé-Gilbert ME, Rettinger A, Douyere A, Meyer M, Iraola G, Picardeau M, Goarant C.
Frontiers in Microbiology 9: 816. doi: 10.3389/fmicb.2018.00816. Texte intégral

Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence.
Thibeaux R, Iraola G, Ferrés I, Bierque E, Girault D, Soupé-Gilbert ME, Picardeau M, Goarant C. 
Microbial Genomics  2018:4. doi: 10.1099/mgen.0.000144. Texte intégral

Advances and challenges in barcoding pathogenic and environmental Leptospira.
Guernier V, Allan KJ, Goarant C. 
Parasitology 145:595-607. doi: 10.1017/S0031182017001147. Vers PubMed


Continuous excretion of Leptospira borgpetersenii Ballum in mice assessed by viability-quantitative PCR.
Soupé-Gilbert ME, Bierque E, Geroult S, Teurlai M, Goarant C.
Am J Trop Med Hyg 97(4):1088-1093. doi: 10.4269/ajtmh.17-0114. Vers PubMed

Diagnostic présomptif de leptospirose avant la séroconversion : à propos de 338 cas à Wallis et Futuna de 2008 à 2015.
Massenet D, Couteaux C, Goarant C.
Annales de Biologie Clinique 75: 167-172. Vers PubMed

High level of IL-10 expression in the blood of animal models possibly relates to resistance against leptospirosis.
Matsui M, Roche L, Soupé-Gilbert ME, Hasan M, Monchy D, Goarant C.
Cytokine 96: 144-151. Vers PubMed

Seeking the environmental source of Leptospirosis reveals durable bacterial viability in river soils.
Thibeaux R, Geroult S, Benezech C, Chabaud S, Soupé-Gilbert ME, Girault D, Bierque E, Goarant C.
PLoS Negl Trop Dis 11: e0005414. Texte intégral/Full text

Isolation of Leptospira from blood culture bottles.
Girault D, Soupé-Gilbert ME, Geroult S, Colot J, Goarant C
Diag Microbiol Infect Dis 88(1):17-19. Texte intégral/Full text


Leptospirosis: risk factors and management challenges in developing countries.
Goarant C.
Res Rep Trop Med 7: 49-62. Texte intégral

Cytokine and Chemokine expression in kidneys during chronic leptospirosis in reservoir and susceptible animal models.
Matsui M, Roche L, Geroult S, Soupé-Gilbert ME, Monchy D, Huerre M, Goarant C. 
PLoS One 11(5):e0156084. Texte intégral

Zika virus infection as an unexpected finding in a leptospirosis patient.
Biron A, Cazorla C, Amar J, Pfannstiel A, Dupont-Rouzeyrol M, Goarant C. 
JMM Case Reports 3(3):e005033. Texte intégral


An unprecedented high incidence of leptospirosis in Futuna, South Pacific, 2004 – 2014, evidenced by retrospective analysis of surveillance data
Massenet D, Yvon JF, Couteaux C, Goarant C.
PLoS One 10:e0142063. Texte intégral

Leptospirosis after a stay in Madagascar.
Pagès F, Kuli B, Moiton MP, Goarant C, Jaffar-Bandjee MC
Journal of Travel Medicine 22:136-139. Vers PubMed

Severity markers in severe leptospirosis: a cohort study.
Makulski M, Boisier P, Lacassin F, Soupé-Gilbert ME, Mauron C, Bruyère-Ostells L, Bonte D, Barguil Y, Gourinat AC, Matsui M, Vernel-Pauillac F, Goarant C
European Journal of Clinical Microbiology and Infectious Diseases 34:687-695. Vers PubMed

Experimental hamster infection with a strain of Leptospira borgpetersenii Ballum isolated from a reservoir mouse in New Caledonia.
Matsui M, Roche L, Soupé-Gilbert ME, Roudier M, Moniquet V, Goarant C
Am J Trop Med Hyg 92:982-985. Vers PubMed


A putative regulatory genetic locus modulates virulence in the pathogen Leptospira interrogans.
Eshghi A, Becam J, Lambert A, Sismeiro O, Dillies M-A, Jagla B, Wunder E, Ko A, Coppee J-Y, Goarant C, Picardeau M.
Infection and Immunity 82(6):2542-2552. Vers PubMed

Though not reservoirs, dogs might transmit Leptospira in New Caledonia.
Gay N, Soupé-Gilbert ME, Goarant C.
International journal of environmental research and public health 11:4316-4325. Texte intégral

El Niño Southern Oscillation and leptospirosis outbreaks in New Caledonia.
Weinberger D, Baroux N, Grangeon J-P, Ko AI, Goarant C.
PLoS neglected tropical diseases 8(4):e2798. Texte intégral

An exotic case of leptospirosis imported into an endemic area.
Goarant C, Colot J, Faelchlin E, Ponchet M, Soupé-Gilbert ME, Descloux E, Gourinat A-C.
Travel Medicine and Infectious Disease 12:198-200. Vers PubMed

Leptospirosis: Time to move to molecular epidemiology: Comments on « Reassessment of MLST schemes for Leptospira spp. typing worldwide » by Varni and colleagues.
Goarant C.
Infection Genetics and Evolution 2014:484-485. Vers PubMed


Association between age and severity to leptospirosis in children.
Guerrier G, Hie P, Gourinat AC, Huguon E, Polfrit Y, Goarant C, D’Ortenzio E, Missote I. 2013.
PLoS Neglected Tropical Diseases 7:e2436. Texte intégral

Sensitivity and specificity of a new Vertical Flow Rapid Diagnostic Test for the serodiagnosis of human leptospirosis.
Goarant C, Bourhy P, D’Ortenzio E, Dartevelle S, Mauron C, Soupé-Gilbert ME, Bruyère-Ostells L, Gourinat AC, Picardeau M, Nato F, Chanteau S.
PLoS Neglected Tropical Diseases 7:e2289. Texte intégral

Leptospirosis risk increases with changes in species composition of rat populations.
Theuerkauf J, Perez J, Taugamoa A, Niutoua I, Labrousse D, Gula R, Bogdanowicz H, Jourdan H, Goarant C.
Naturwissenschaften 100:385-388. Texte intégral

Risk Factors and Predictors of Severe Leptospirosis in New Caledonia.
Tubiana S, Mikulski M, Becam J, Lacassin F, Lefèvre P, Gourinat AC, Goarant C, D’Ortenzio E.
PLoS Neglected Tropical Diseases 7:e1991. Texte intégral


Differential in vivo gene expression of major Leptospira proteins in resistant or susceptible animal models.
Matsui, M., M. E. Soupe, J. Becam, and C. Goarant.
Applied and Environmental Microbiology 78(17):6372-6376. vers PubMed


Rodent abundance dynamics and leptospirosis carriage in an area of hyper-endemicity in New Caledonia.
Perez J, Brescia F, Becam J, Mauron C, Goarant C
PLoS Neglected Tropical Diseases 5(10):e1361. Texte intégral

Gene expression profiles of immune mediators and histopathological findings in animal models of leptospirosis : comparison between susceptible hamsters and resistant mice.
Matsui M, Rouleau V, Bruyère-Ostells L, Goarant C
Infection and Immunity 79(11):4480-4492. vers PubMed


Differential cytokine gene expression according to outcome in a hamster model of leptospirosis.
Vernel-Pauillac F, Goarant C
PloS Neglected Tropical Diseases 2010; 4(1):e582. Texte intégral

Rapid Leptospira identification by direct sequencing of the diagnostic PCR products in New Caledonia.
Perez J, Goarant C.
BMC Microbiology 10:325. Texte intégral

[Hospital based active surveillance of human leptospirosis in Cambodia.].
Berlioz-Arthaud A, Guillard B, Goarant C, Hem S.
Bulletin de la Société de Pathologie Exotique 103(2):111-118. vers PubMed


Leptospira : the dawn of the molecular genetics era for an emerging zoonotic pathogen.
Ko AI, Goarant C, Picardeau M.
Nature Reviews Microbiology 7(10):736-47. vers PubMed

Outbreak of leptospirosis in New Caledonia : diagnosis issues and burden of disease.
Goarant C, Laumond-Barny S, Perez J, Vernel-Pauillac F, Chanteau S, Guigon A.
Tropical Medicine and International Health 14(8):926-9. vers PubMed


Bilan de cinq années de surveillance biologique de la leptospirose humaine en Nouvelle-Calédonie (2001-2005).
Berlioz-Arthaud A, Merien F, Baranton G. 
Bulletin de la Société de Pathologie Exotique 100: 133-138. vers PubMed


Proinflammatory and immunomodulatory cytokine mRNA time course profiles in hamsters infected with a virulent variant of Leptospira interrogans.
Vernel-Pauillac F, Merien F.
Infection and Immunity 74(7):4172-9. Texte intégral

Application of multilocus variable-number tandem-repeat analysis for molecular typing of the agent of leptospirosis.
Salaün L, Mérien F, Gurianova S, Baranton G, Picardeau M. 2006.
Journal of Clinical Microbiology 44(11):3954-62.Texte intégral


A rapid and quantitative method for the detection of Leptospira species in human leptospirosis.
Merien F, Portnoi D, Bourhy P, Charavay F, Berlioz-Arthaud A, Baranton G.
FEMS Microbiology Letters 249(1):139-47. vers PubMed