2026
Free-living amoebae act as transient permissive hosts for Leptospira spp.
Adriana Luga, Catherine Inizan, Eva Meunier, Amélie Albon, Valérie Burtet-Sarramegna, Mathieu Picardeau, Cyrille Goarant & Roman Thibeaux.
En révision dans Plos Neglected Tropical Diseases.
Comparison of Leptosira concentrations in two rivers within contrasting catchments in a Leptospirosis hotspot.
Thibeaux, R, Genthon, P, Govan, R, Selmaoui-Folcher, N, Peltier, A, Kainiu, M, Soupé-Gilbert, M.-E, Yu, O, Tramier, C, Wijesurriya, K, Goarant, C
En révision dans Journal of Contaminant Hydrology
Epidemiology, Clinical Characteristics, and Biomarkers Associated with Severe Leptospirosis During the 2021 Outbreak in New Caledonia
Cécile Cazorla, Julie Cagliero, Clara Deodati, Benjamin Jeanne, Marie-Estelle Soupe-Gibert, Julien Colot, Arnaud Cannet, Ann-Claire Gourinat, Patrick Lefevre, Julien Lebon, François Baur, Cyrille Goarant, Anne Loarec, Roman Thibeaux
En soumission
2025
A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms.
Davignon G, Thibeaux R. J Vis Exp. 2025 Dec 19;(226). doi: 10.3791/69511. PMID: 41490174
Detection of pathogenic Leptospira spp. in peridomestic Rattus norvegicus in Hong Kong.
Uea-Anuwong T, Wen C, Qing H, Li F, Thibeaux R, Magouras I. One Health. 2025 Jul 30;21:101158. doi: 10.1016/j.onehlt.2025.101158. eCollection 2025 Dec. PMID: 40822317 Free PMC article.
Spatio-temporal risk prediction of leptospirosis: A machine-learning-based approach.
Govan R, Scherrer R, Fougeron B, Laporte-Magoni C, Thibeaux R, Genthon P, Fournier-Viger P, Goarant C, Selmaoui-Folcher N. PLoS Negl Trop Dis. 2025 Jan 16;19(1):e0012755. doi: 10.1371/journal.pntd.0012755. eCollection 2025 Jan.PMID: 39820517
Anti-inflammatory cytokine profile and Jarisch-Herxheimer reaction in Leptospirosis patients: A prospective case-series study in New Caledonia.
Cagliero J, Loarec A, Lebon J, Baur F, Lefevre P, Follenfant E, Goarant C, Ukeiwe D, Colot J, Tardieu S, Werts C, Cazorla C. PLoS Negl Trop Dis. 2025 Sep 23;19(9):e0013189. doi: 10.1371/journal.pntd.0013189. eCollection 2025 Sep.PMID: 40986630 Free PMC article.
2024
Davignon G, Pietrosemoli N, Benaroudj N, Soupé-Gilbert ME, Cagliero J, Turc É, Picardeau M, Guentas L, Goarant C, Thibeaux R. NPJ Biofilms Microbiomes. 2024 Sep 30;10(1):95. doi: 10.1038/s41522-024-00570-0. PMID: 39349472Free PMC article.
Rainfall-driven resuspension of pathogenic Leptospira in a leptospirosis hotspot.
Thibeaux R, Genthon P, Govan R, Selmaoui-Folcher N, Tramier C, Kainiu M, Soupé-Gilbert ME, Wijesuriya K, Goarant C. Sci Total Environ. 2024 Feb 10;911:168700. doi: 10.1016/j.scitotenv.2023.168700. Epub 2023 Nov 20. PMID: 37992819
2023
Leptospirosis: toward a better understanding of the environmental lifestyle of Leptospira.
Davignon G, Cagliero J, Guentas L, Bierque E, Genthon P, Gunkel-Grillon P, Juillot F, Kainiu M, Laporte-Magoni C, Picardeau M, Selmaoui-Folcher N, Soupé-Gilbert M-E, Tramier C, Vilanova J, Wijesuriya K, Thibeaux R and Goarant C (2023). Front. Water 5:1195094. doi: 10.3389/frwa.2023.1195094
2022
Leptospira
Goarant C, Adler B, De la Peña Moctezuma A.
in: Prescott, J.F., Boyce, J., MacInnes, J.I., Rycroft, A.N., Immerseel, F.V., Vázquez-Boland, J.A. (Eds.), Pathogenesis of Bacterial Infections in Animals, 5th Edition. Wiley Blackwell, pp. 502-527. Site de l’éditeur
Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling.
Cagliero J, Vernel-Pauillac F, Murray G, Adler B, Matsui M, Werts C. Frontiers in immunology 13, 911778. Texte intégral
Original Leptospira spp. in island native terrestrial mammals: a case study in Pteropus spp. bats of New Caledonia.
Soupé-Gilbert ME, Oedin M, Kainiu M, Girault D, Figuet O, Brescia F, Goarant C.
Transboundary and Emerging Diseases. Site de l’éditeur
Unraveling the invisible leptospirosis in mainland Southeast Asia and its fate under climate change.Douchet L, Goarant C, Mangeas M, Menkes C, Hinjoy S, Herbreteau V.
Science of the Total Environment 832:155018. Texte intégral
Clinical Evaluation of the Modified Faine Criteria in Patients Admitted with Suspected Leptospirosis to the Territorial Hospital, New Caledonia, 2018 to 2019.Guibreteau H, Tarantola A, Goarant C, Gervolino S, Gourinat AC, Colot J, Cazorla C, Klement-Frutos E.
The American journal of tropical medicine and hygiene 106(2):486-493. Site de l’éditeur
2021
Leptospira ainlahdjerensis sp. nov., Leptospira ainazelensis sp. nov., Leptospira abararensis sp. nov. and Leptospira chreensis sp. nov., four new species isolated from water sources in Algeria.
Korba AA, Lounici H, Kainiu M, Vincent AT, Mariet JF, Veyrier FJ, Goarant C, Dellagi K, Picardeau M.
International journal of systematic and evolutionary microbiology 71(12) Site de l’éditeur
Ending the neglect of treatable bacterial zoonoses responsible for non-malarial fevers
Goarant C, Dellagi K, Picardeau M.
Yale Journal of Biology and Medicine 94(2):351-360. Texte intégral/Full text
2020
Isolation and Culture of Leptospira from Clinical and Environmental Samples.
Goarant C, Girault D, Thibeaux R, Soupé-Gilbert ME, 2020.
Methods Mol Biol 2134: 1-9. site de l’éditeur
Use of MALDI-ToF Mass Spectrometry for Identification of Leptospira.
Girault D, Kainiu M, Barsac E, Thibeaux R, Goarant C, 2020.
Methods Mol Biol 2134: 23-29. site de l’éditeur
Biofilm Formation and Quantification Using the 96-Microtiter Plate.
Thibeaux R, Kainiu M, Goarant C, 2020.
Methods Mol Biol 2134: 207-214. site de l’éditeur
Age-specific epidemiology of human leptospirosis in New Caledonia
Klement-Frutos E, Tarantola A, Gourinat AC, Floury L, Goarant C.PLoS ONE 15(11):e0242886. Texte intégral/Full text
Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.Holzapfel M, Bonhomme D, Cagliero J, Vernel-Pauillac F, Fanton d’Andon M, Bortolussi S, Fiette L, Goarant C, Wunder EA, Picardeau M, Ko AI, Werling D, Matsui M, Boneca IG, Werts C.Frontiers in Immunology. 11:2007 Texte intégral
Leptospira interrogans retains direct virulence after long starvation in water.
Bierque E, Soupé-Gilbert ME, Thibeaux R, Girault D, Guentas L, Goarant C.Current Microbiology 77(10):3035-3043. Site de l’éditeur
The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMP-controlled biofilm production.
Thibeaux R, Soupé-Gilbert ME, Kainiu M, Girault D, Bierque E, Fernandes J, Bähre H, Douyère A, Eskenazi N, Vinh J, Picardeau M, Goarant C.NPJ Biofilms Microbiomes. 6(1):24 Texte intégral/Full text
Leptospira interrogans and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia.
Philip N, Bahtiar Affendy N, Ramli S, Arif M, Raja P, Nagandran E, Renganathan P, Taib NM, Masri SN, Yuhana MY, Than L, Seganathirajah M, Goarant C, Goris M, Sekawi Z, Neela VK
PLoS Negl Trop Dis 14(3):e0008197. Texte intégral/Full text
A systematic review of Leptospira in water and soil environments
Bierque E, Thibeaux R, Girault D, Soupé-Gilbert ME, Goarant C
PLoS One 15(1):e0227055. Texte intégral/Full text
2019
Leptospira and leptospirosis
Goarant C, Trueba G, Bierque E, Thibeaux R, Davis B, De la Peña Moctezuma A, 2019
In: J.B. Rose and B. Jiménez-Cisneros, (eds) Global Water Pathogen Project. ( A. Pruden, N. Ashbolt and J. Miller (eds) Part 3 Bacteria) Michigan State University, E. Lansing, MI, UNESCO.
http://www.waterpathogens.org/book/Leptospira-and-leptospirosis Version pdf
Health Challenges of the Pacific Region: Insights From History, Geography, Social Determinants, Genetics, and the Microbiome
Horwood PF, Tarantola A, Goarant C, Matsui M, Klement E, Umezaki M, Navarro S, Greenhill AR
Front. Immunol. 10: 2184. Texte intégral/Full text
Counting Oceanians of Non-European, Non-Asian descent (ONENA) in the South Pacific to make them count in global health
Tarantola A, Horwood PF, Goarant C, Buffière B, Bertrand S, Merilles OE, Pedron T, Klement-Frutos E, Sansonetti P, Quintana-Murci L, Richard V
Trop Med Infect Dis 4: E114. Texte intégral/Full text
Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics
Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, Ismail N, Mohd Khalid MK, Amran F, Masuzawa T, Nakao R, Amara Khorba A, Bourhy P, Veyrier FJ, Picardeau M
PLoS Negl Trop Dis 13(5):e0007270. Texte intégral/Full text Format pdf
Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect
Goarant C, Picardeau M, Morand S, K Marie McIntyre
J Glob Health 9(1):010302. Texte intégral/Full text Format pdf
2018
Leptospirosis in French historical medical literature – Weil’s disease or Kelsch’s disease?
Tarantola A, Goarant C.
Am J Trop Med Hyg 99(6):1366-1368. doi: 10.4269/ajtmh.18-0629. Vers PubMed
A large leptospirosis outbreak following successive severe floods in Fiji, 2012.
Togami E, Kama M, Goarant C, Craig SB, Lau C, Ritter JM, Imrie A, Ko A, Nilles E.
Am J Trop Med Hyg 99(4):849-851. doi: 10.4269/ajtmh.18-0335. Vers PubMed
Evidence of human leptospirosis cases in a cohort of febrile patients in Bangui, Central African Republic: a retrospective study, 2012-2015.
Rubbo PA, Soupé-Gilbert ME, Golongba DM, Mbombo F, Girault D, Nakoune E, Lombart JP, Breurec S, Goarant C.
BMC Infect Dis 18(1):376. doi: 10.1186/s12879-018-3298-z. Texte intégral/Full text
High incidence of leptospirosis in an observational study of hospital outpatients in Vanuatu highlights the need for improved awareness and diagnostic capacities.
Pakoa JG, Soupé-Gilbert ME, Girault D, Takau D, Gaviga J, Gourinat AC, Tarantola A, Goarant C.
PLoS Negl Trop Dis 12(6):e0006564. doi: 10.1371/journal.pntd.0006564. Texte intégral/Full text
A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity.
Guernier V, Goarant C, Benshop J, Lau CL.
PLoS Negl Trop Dis 2018 ; 12:e0006503. doi: 10.1371/
journal.pntd.0006503. Texte intégral
Biodiversity of environmental Leptospira: improving identification and revisiting the diagnosis.
Thibeaux R, Girault D, Bierque E, Soupé-Gilbert ME, Rettinger A, Douyere A, Meyer M, Iraola G, Picardeau M, Goarant C.
Frontiers in Microbiology 9: 816. doi: 10.3389/fmicb.2018.00816. Texte intégral
Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence.
Thibeaux R, Iraola G, Ferrés I, Bierque E, Girault D, Soupé-Gilbert ME, Picardeau M, Goarant C.
Microbial Genomics 2018:4. doi: 10.1099/mgen.0.000144. Texte intégral
Advances and challenges in barcoding pathogenic and environmental Leptospira.
Guernier V, Allan KJ, Goarant C.
Parasitology 145:595-607. doi: 10.1017/S0031182017001147. Vers PubMed
2017
Continuous excretion of Leptospira borgpetersenii Ballum in mice assessed by viability-quantitative PCR.
Soupé-Gilbert ME, Bierque E, Geroult S, Teurlai M, Goarant C.
Am J Trop Med Hyg 97(4):1088-1093. doi: 10.4269/ajtmh.17-0114. Vers PubMed
Diagnostic présomptif de leptospirose avant la séroconversion : à propos de 338 cas à Wallis et Futuna de 2008 à 2015.
Massenet D, Couteaux C, Goarant C.
Annales de Biologie Clinique 75: 167-172. Vers PubMed
High level of IL-10 expression in the blood of animal models possibly relates to resistance against leptospirosis.
Matsui M, Roche L, Soupé-Gilbert ME, Hasan M, Monchy D, Goarant C.
Cytokine 96: 144-151. Vers PubMed
Seeking the environmental source of Leptospirosis reveals durable bacterial viability in river soils.
Thibeaux R, Geroult S, Benezech C, Chabaud S, Soupé-Gilbert ME, Girault D, Bierque E, Goarant C.
PLoS Negl Trop Dis 11: e0005414. Texte intégral/Full text
Isolation of Leptospira from blood culture bottles.
Girault D, Soupé-Gilbert ME, Geroult S, Colot J, Goarant C
Diag Microbiol Infect Dis 88(1):17-19. Texte intégral/Full text
2016 and before
Leptospirosis: risk factors and management challenges in developing countries.
Goarant C.
Res Rep Trop Med 7: 49-62. Texte intégral
Leptospirosis: risk factors and management challenges in developing countries.
Goarant C.
Res Rep Trop Med 7: 49-62. Texte intégral
Cytokine and Chemokine expression in kidneys during chronic leptospirosis in reservoir and susceptible animal models.
Matsui M, Roche L, Geroult S, Soupé-Gilbert ME, Monchy D, Huerre M, Goarant C.
PLoS One 11(5):e0156084. Texte intégral
Zika virus infection as an unexpected finding in a leptospirosis patient.
Biron A, Cazorla C, Amar J, Pfannstiel A, Dupont-Rouzeyrol M, Goarant C.
JMM Case Reports 3(3):e005033. Texte intégral
An unprecedented high incidence of leptospirosis in Futuna, South Pacific, 2004 – 2014, evidenced by retrospective analysis of surveillance data
Massenet D, Yvon JF, Couteaux C, Goarant C.
PLoS One 10:e0142063. Texte intégral
Leptospirosis after a stay in Madagascar.
Pagès F, Kuli B, Moiton MP, Goarant C, Jaffar-Bandjee MC
Journal of Travel Medicine 22:136-139. Vers PubMed
Severity markers in severe leptospirosis: a cohort study.
Makulski M, Boisier P, Lacassin F, Soupé-Gilbert ME, Mauron C, Bruyère-Ostells L, Bonte D, Barguil Y, Gourinat AC, Matsui M, Vernel-Pauillac F, Goarant C
European Journal of Clinical Microbiology and Infectious Diseases 34:687-695. Vers PubMed
Experimental hamster infection with a strain of Leptospira borgpetersenii Ballum isolated from a reservoir mouse in New Caledonia.
Matsui M, Roche L, Soupé-Gilbert ME, Roudier M, Moniquet V, Goarant C
Am J Trop Med Hyg 92:982-985. Vers PubMed
A putative regulatory genetic locus modulates virulence in the pathogen Leptospira interrogans.
Eshghi A, Becam J, Lambert A, Sismeiro O, Dillies M-A, Jagla B, Wunder E, Ko A, Coppee J-Y, Goarant C, Picardeau M. 2014
Infection and Immunity 82(6):2542-2552. Vers PubMed
Though not reservoirs, dogs might transmit Leptospira in New Caledonia.
Gay N, Soupé-Gilbert ME, Goarant C. 2014
International journal of environmental research and public health 11:4316-4325. Texte intégral
El Niño Southern Oscillation and leptospirosis outbreaks in New Caledonia.
Weinberger D, Baroux N, Grangeon J-P, Ko AI, Goarant C. 2014
PLoS neglected tropical diseases 8(4):e2798. Texte intégral
An exotic case of leptospirosis imported into an endemic area.
Goarant C, Colot J, Faelchlin E, Ponchet M, Soupé-Gilbert ME, Descloux E, Gourinat A-C. 2014
Travel Medicine and Infectious Disease 12:198-200. Vers PubMed
Leptospirosis: Time to move to molecular epidemiology: Comments on « Reassessment of MLST schemes for Leptospira spp. typing worldwide » by Varni and colleagues.
Goarant C. 2014
Infection Genetics and Evolution 2014:484-485. Vers PubMed
Association between age and severity to leptospirosis in children.
Guerrier G, Hie P, Gourinat AC, Huguon E, Polfrit Y, Goarant C, D’Ortenzio E, Missote I. 2013.
PLoS Neglected Tropical Diseases 7:e2436. Texte intégral
Sensitivity and specificity of a new Vertical Flow Rapid Diagnostic Test for the serodiagnosis of human leptospirosis.
Goarant C, Bourhy P, D’Ortenzio E, Dartevelle S, Mauron C, Soupé-Gilbert ME, Bruyère-Ostells L, Gourinat AC, Picardeau M, Nato F, Chanteau S. 2013
PLoS Neglected Tropical Diseases 7:e2289. Texte intégral
Leptospirosis risk increases with changes in species composition of rat populations.
Theuerkauf J, Perez J, Taugamoa A, Niutoua I, Labrousse D, Gula R, Bogdanowicz H, Jourdan H, Goarant C. 2013
Naturwissenschaften 100:385-388. Texte intégral
Risk Factors and Predictors of Severe Leptospirosis in New Caledonia.
Tubiana S, Mikulski M, Becam J, Lacassin F, Lefèvre P, Gourinat AC, Goarant C, D’Ortenzio E. 2013
PLoS Neglected Tropical Diseases 7:e1991. Texte intégral
Differential in vivo gene expression of major Leptospira proteins in resistant or susceptible animal models.
Matsui, M., Soupe M. E., Becam J., Goarant C. 2012
Applied and Environmental Microbiology 78(17):6372-6376. vers PubMed
Rodent abundance dynamics and leptospirosis carriage in an area of hyper-endemicity in New Caledonia.
Perez J, Brescia F, Becam J, Mauron C, Goarant C. 2011
PLoS Neglected Tropical Diseases 5(10):e1361. Texte intégral
Gene expression profiles of immune mediators and histopathological findings in animal models of leptospirosis : comparison between susceptible hamsters and resistant mice.
Matsui M, Rouleau V, Bruyère-Ostells L, Goarant C. 2011
Infection and Immunity 79(11):4480-4492. vers PubMed
Differential cytokine gene expression according to outcome in a hamster model of leptospirosis.
Vernel-Pauillac F, Goarant C 2010
PloS Neglected Tropical Diseases 2010; 4(1):e582. Texte intégral
Rapid Leptospira identification by direct sequencing of the diagnostic PCR products in New Caledonia.
Perez J, Goarant C. 2010
BMC Microbiology 10:325. Texte intégral
[Hospital based active surveillance of human leptospirosis in Cambodia.].
Berlioz-Arthaud A, Guillard B, Goarant C, Hem S. 2010
Bulletin de la Société de Pathologie Exotique 103(2):111-118. vers PubMed
Leptospira : the dawn of the molecular genetics era for an emerging zoonotic pathogen.
Ko AI, Goarant C, Picardeau M. 2009
Nature Reviews Microbiology 7(10):736-47. vers PubMedv
[Hospital based active surveillance of human leptospirosis in Cambodia.].
Berlioz-Arthaud A, Guillard B, Goarant C, Hem S. 2010
Bulletin de la Société de Pathologie Exotique 103(2):111-118. vers PubMed
Leptospira : the dawn of the molecular genetics era for an emerging zoonotic pathogen.
Ko AI, Goarant C, Picardeau M. 2009
Nature Reviews Microbiology 7(10):736-47. vers PubMed
Outbreak of leptospirosis in New Caledonia : diagnosis issues and burden of disease.
Goarant C, Laumond-Barny S, Perez J, Vernel-Pauillac F, Chanteau S, Guigon A. 2009
Tropical Medicine and International Health 14(8):926-9. vers PubMed
Bilan de cinq années de surveillance biologique de la leptospirose humaine en Nouvelle-Calédonie (2001-2005).
Berlioz-Arthaud A, Merien F, Baranton G. 2007
Bulletin de la Société de Pathologie Exotique 100: 133-138. vers PubMed
Proinflammatory and immunomodulatory cytokine mRNA time course profiles in hamsters infected with a virulent variant of Leptospira interrogans.
Vernel-Pauillac F, Merien F. 2006
Infection and Immunity 74(7):4172-9. Texte intégral
Application of multilocus variable-number tandem-repeat analysis for molecular typing of the agent of leptospirosis.
Salaün L, Mérien F, Gurianova S, Baranton G, Picardeau M. 2006.
Journal of Clinical Microbiology 44(11):3954-62.Texte intégral
A rapid and quantitative method for the detection of Leptospira species in human leptospirosis.
Merien F, Portnoi D, Bourhy P, Charavay F, Berlioz-Arthaud A, Baranton G. 2005
FEMS Microbiology Letters 249(1):139-47. vers PubMed