2022

Leptospira
Goarant C, Adler B, De la Peña Moctezuma A.
in: Prescott, J.F., Boyce, J., MacInnes, J.I., Rycroft, A.N., Immerseel, F.V., Vázquez-Boland, J.A. (Eds.), Pathogenesis of Bacterial Infections in Animals, 5th Edition. Wiley Blackwell, pp. 502-527. Site de l’éditeur

Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling.
Cagliero J, Vernel-Pauillac F, Murray G, Adler B, Matsui M, Werts C. Frontiers in immunology 13, 911778. Texte intégral

Original Leptospira spp. in island native terrestrial mammals: a case study in Pteropus spp. bats of New Caledonia.
Soupé-Gilbert ME, Oedin M, Kainiu M, Girault D, Figuet O, Brescia F, Goarant C.
Transboundary and Emerging Diseases. Site de l’éditeur

Unraveling the invisible leptospirosis in mainland Southeast Asia and its fate under climate change.
Douchet L, Goarant C, Mangeas M, Menkes C, Hinjoy S, Herbreteau V.
Science of the Total Environment 832:155018. Texte intégral

Clinical Evaluation of the Modified Faine Criteria in Patients Admitted with Suspected Leptospirosis to the Territorial Hospital, New Caledonia, 2018 to 2019.
Guibreteau H, Tarantola A, Goarant C, Gervolino S, Gourinat AC, Colot J, Cazorla C, Klement-Frutos E.
The American journal of tropical medicine and hygiene 106(2):486-493. Site de l’éditeur

2021

Leptospira ainlahdjerensis sp. nov., Leptospira ainazelensis sp. nov., Leptospira abararensis sp. nov. and Leptospira chreensis sp. nov., four new species isolated from water sources in Algeria.
Korba AA, Lounici H, Kainiu M, Vincent AT, Mariet JF, Veyrier FJ, Goarant C, Dellagi K, Picardeau M.
International journal of systematic and evolutionary microbiology 71(12) Site de l’éditeur

Ending the neglect of treatable bacterial zoonoses responsible for non-malarial fevers
Goarant C, Dellagi K, Picardeau M.
Yale Journal of Biology and Medicine 94(2):351-360. Texte intégral/Full text

2020

Isolation and Culture of Leptospira from Clinical and Environmental Samples.
Goarant C, Girault D, Thibeaux R, Soupé-Gilbert ME, 2020.
Methods Mol Biol 2134: 1-9. site de l’éditeur

Use of MALDI-ToF Mass Spectrometry for Identification of Leptospira.
Girault D, Kainiu M, Barsac E, Thibeaux R, Goarant C, 2020.
Methods Mol Biol 2134: 23-29. site de l’éditeur

Biofilm Formation and Quantification Using the 96-Microtiter Plate.
Thibeaux R, Kainiu M, Goarant C, 2020.
Methods Mol Biol 2134: 207-214. site de l’éditeur

Age-specific epidemiology of human leptospirosis in New Caledonia
Klement-Frutos E, Tarantola A, Gourinat AC, Floury L, Goarant C.
PLoS ONE 15(11):e0242886.  Texte intégral/Full text

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.
Holzapfel M, Bonhomme D, Cagliero J, Vernel-Pauillac F, Fanton d’Andon M, Bortolussi S, Fiette L, Goarant C, Wunder EA, Picardeau M, Ko AI, Werling D, Matsui M, Boneca IG, Werts C.
Frontiers in Immunology. 11:2007 Texte intégral

Leptospira interrogans retains direct virulence after long starvation in water.
Bierque E, Soupé-Gilbert ME, Thibeaux R, Girault D, Guentas L, Goarant C.
Current Microbiology 77(10):3035-3043.  Site de l’éditeur

The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMP-controlled biofilm production.
Thibeaux R, Soupé-Gilbert ME, Kainiu M, Girault D, Bierque E, Fernandes J, Bähre H, Douyère A, Eskenazi N, Vinh J, Picardeau M, Goarant C.
NPJ Biofilms Microbiomes. 6(1):24 Texte intégral/Full text

Leptospira interrogans  and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia.
Philip N, Bahtiar Affendy N, Ramli S, Arif M, Raja P, Nagandran E, Renganathan P, Taib NM, Masri SN, Yuhana MY, Than L, Seganathirajah M, Goarant C, Goris M, Sekawi Z, Neela VK
PLoS Negl Trop Dis 14(3):e0008197. Texte intégral/Full text

A systematic review of Leptospira in water and soil environments
Bierque E, Thibeaux R, Girault D, Soupé-Gilbert ME, Goarant C
PLoS One 15(1):e0227055. Texte intégral/Full text

2019

Leptospira and leptospirosis
Goarant C, Trueba G, Bierque E, Thibeaux R, Davis B, De la Peña Moctezuma A, 2019
In: J.B. Rose and B. Jiménez-Cisneros, (eds) Global Water Pathogen Project. ( A. Pruden, N. Ashbolt and J. Miller (eds) Part 3 Bacteria) Michigan State University, E. Lansing, MI, UNESCO.
http://www.waterpathogens.org/book/Leptospira-and-leptospirosis Version pdf

Health Challenges of the Pacific Region: Insights From History, Geography, Social Determinants, Genetics, and the Microbiome
Horwood PF, Tarantola A, Goarant C, Matsui M, Klement E, Umezaki M, Navarro S, Greenhill AR
Front. Immunol. 10: 2184. Texte intégral/Full text

Counting Oceanians of Non-European, Non-Asian descent (ONENA) in the South Pacific to make them count in global health
Tarantola A, Horwood PF, Goarant C, Buffière B, Bertrand S, Merilles OE, Pedron T, Klement-Frutos E, Sansonetti P, Quintana-Murci L, Richard V
Trop Med Infect Dis 4: E114. Texte intégral/Full text

Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics
Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, Ismail N, Mohd Khalid MK, Amran F, Masuzawa T, Nakao R, Amara Khorba A, Bourhy P, Veyrier FJ, Picardeau M
PLoS Negl Trop Dis 13(5):e0007270. Texte intégral/Full text Format pdf

Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect
Goarant C, Picardeau M, Morand S, K Marie McIntyre
J Glob Health 9(1):010302. Texte intégral/Full text Format pdf

2018

Leptospirosis in French historical medical literature – Weil’s disease or Kelsch’s disease?
Tarantola A, Goarant C.
Am J Trop Med Hyg 99(6):1366-1368. doi: 10.4269/ajtmh.18-0629. Vers PubMed

A large leptospirosis outbreak following successive severe floods in Fiji, 2012.
Togami E, Kama M, Goarant C, Craig SB, Lau C, Ritter JM, Imrie A, Ko A, Nilles E.
Am J Trop Med Hyg 99(4):849-851. doi: 10.4269/ajtmh.18-0335. Vers PubMed

Evidence of human leptospirosis cases in a cohort of febrile patients in Bangui, Central African Republic: a retrospective study, 2012-2015.
Rubbo PA, Soupé-Gilbert ME, Golongba DM, Mbombo F, Girault D, Nakoune E, Lombart JP, Breurec S, Goarant C.
BMC Infect Dis 18(1):376. doi: 10.1186/s12879-018-3298-z. Texte intégral/Full text

High incidence of leptospirosis in an observational study of hospital outpatients in Vanuatu highlights the need for improved awareness and diagnostic capacities.
Pakoa JG, Soupé-Gilbert ME, Girault D, Takau D, Gaviga J, Gourinat AC, Tarantola A, Goarant C.
PLoS Negl Trop Dis 12(6):e0006564. doi: 10.1371/journal.pntd.0006564. Texte intégral/Full text

A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity.
Guernier V, Goarant C, Benshop J, Lau CL.
PLoS Negl Trop Dis 2018 ; 12:e0006503. doi: 10.1371/
journal.pntd.0006503. Texte intégral

Biodiversity of environmental Leptospira: improving identification and revisiting the diagnosis.
Thibeaux R, Girault D, Bierque E, Soupé-Gilbert ME, Rettinger A, Douyere A, Meyer M, Iraola G, Picardeau M, Goarant C.
Frontiers in Microbiology 9: 816. doi: 10.3389/fmicb.2018.00816. Texte intégral

Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence.
Thibeaux R, Iraola G, Ferrés I, Bierque E, Girault D, Soupé-Gilbert ME, Picardeau M, Goarant C.
Microbial Genomics  2018:4. doi: 10.1099/mgen.0.000144. Texte intégral

Advances and challenges in barcoding pathogenic and environmental Leptospira.
Guernier V, Allan KJ, Goarant C.
Parasitology 145:595-607. doi: 10.1017/S0031182017001147. Vers PubMed

2017

Continuous excretion of Leptospira borgpetersenii Ballum in mice assessed by viability-quantitative PCR.
Soupé-Gilbert ME, Bierque E, Geroult S, Teurlai M, Goarant C.
Am J Trop Med Hyg 97(4):1088-1093. doi: 10.4269/ajtmh.17-0114. Vers PubMed

Diagnostic présomptif de leptospirose avant la séroconversion : à propos de 338 cas à Wallis et Futuna de 2008 à 2015.
Massenet D, Couteaux C, Goarant C.
Annales de Biologie Clinique 75: 167-172. Vers PubMed

High level of IL-10 expression in the blood of animal models possibly relates to resistance against leptospirosis.
Matsui M, Roche L, Soupé-Gilbert ME, Hasan M, Monchy D, Goarant C.
Cytokine 96: 144-151. Vers PubMed

Seeking the environmental source of Leptospirosis reveals durable bacterial viability in river soils.
Thibeaux R, Geroult S, Benezech C, Chabaud S, Soupé-Gilbert ME, Girault D, Bierque E, Goarant C.
PLoS Negl Trop Dis 11: e0005414. Texte intégral/Full text

Isolation of Leptospira from blood culture bottles.
Girault D, Soupé-Gilbert ME, Geroult S, Colot J, Goarant C
Diag Microbiol Infect Dis 88(1):17-19. Texte intégral/Full text

2016 and before

Leptospirosis: risk factors and management challenges in developing countries.
Goarant C.
Res Rep Trop Med 7: 49-62. Texte intégral

Cytokine and Chemokine expression in kidneys during chronic leptospirosis in reservoir and susceptible animal models.
Matsui M, Roche L, Geroult S, Soupé-Gilbert ME, Monchy D, Huerre M, Goarant C.
PLoS One 11(5):e0156084. Texte intégral

Zika virus infection as an unexpected finding in a leptospirosis patient.
Biron A, Cazorla C, Amar J, Pfannstiel A, Dupont-Rouzeyrol M, Goarant C.
JMM Case Reports 3(3):e005033. Texte intégral

An unprecedented high incidence of leptospirosis in Futuna, South Pacific, 2004 – 2014, evidenced by retrospective analysis of surveillance data
Massenet D, Yvon JF, Couteaux C, Goarant C.
PLoS One 10:e0142063. Texte intégral

Leptospirosis after a stay in Madagascar.
Pagès F, Kuli B, Moiton MP, Goarant C, Jaffar-Bandjee MC
Journal of Travel Medicine 22:136-139. Vers PubMed

Severity markers in severe leptospirosis: a cohort study.
Makulski M, Boisier P, Lacassin F, Soupé-Gilbert ME, Mauron C, Bruyère-Ostells L, Bonte D, Barguil Y, Gourinat AC, Matsui M, Vernel-Pauillac F, Goarant C
European Journal of Clinical Microbiology and Infectious Diseases 34:687-695. Vers PubMed

Experimental hamster infection with a strain of Leptospira borgpetersenii Ballum isolated from a reservoir mouse in New Caledonia.
Matsui M, Roche L, Soupé-Gilbert ME, Roudier M, Moniquet V, Goarant C
Am J Trop Med Hyg 92:982-985. Vers PubMed

A putative regulatory genetic locus modulates virulence in the pathogen Leptospira interrogans.
Eshghi A, Becam J, Lambert A, Sismeiro O, Dillies M-A, Jagla B, Wunder E, Ko A, Coppee J-Y, Goarant C, Picardeau M. 2014
Infection and Immunity 82(6):2542-2552. Vers PubMed

Though not reservoirs, dogs might transmit Leptospira in New Caledonia.
Gay N, Soupé-Gilbert ME, Goarant C. 2014
International journal of environmental research and public health 11:4316-4325. Texte intégral

El Niño Southern Oscillation and leptospirosis outbreaks in New Caledonia.
Weinberger D, Baroux N, Grangeon J-P, Ko AI, Goarant C. 2014
PLoS neglected tropical diseases 8(4):e2798. Texte intégral

An exotic case of leptospirosis imported into an endemic area.
Goarant C, Colot J, Faelchlin E, Ponchet M, Soupé-Gilbert ME, Descloux E, Gourinat A-C. 2014
Travel Medicine and Infectious Disease 12:198-200. Vers PubMed

Leptospirosis: Time to move to molecular epidemiology: Comments on « Reassessment of MLST schemes for Leptospira spp. typing worldwide » by Varni and colleagues.
Goarant C. 2014
Infection Genetics and Evolution 2014:484-485. Vers PubMed

Association between age and severity to leptospirosis in children.
Guerrier G, Hie P, Gourinat AC, Huguon E, Polfrit Y, Goarant C, D’Ortenzio E, Missote I. 2013.
PLoS Neglected Tropical Diseases 7:e2436. Texte intégral

Sensitivity and specificity of a new Vertical Flow Rapid Diagnostic Test for the serodiagnosis of human leptospirosis.
Goarant C, Bourhy P, D’Ortenzio E, Dartevelle S, Mauron C, Soupé-Gilbert ME, Bruyère-Ostells L, Gourinat AC, Picardeau M, Nato F, Chanteau S. 2013
PLoS Neglected Tropical Diseases 7:e2289. Texte intégral

Leptospirosis risk increases with changes in species composition of rat populations.
Theuerkauf J, Perez J, Taugamoa A, Niutoua I, Labrousse D, Gula R, Bogdanowicz H, Jourdan H, Goarant C. 2013
Naturwissenschaften 100:385-388. Texte intégral

Risk Factors and Predictors of Severe Leptospirosis in New Caledonia.
Tubiana S, Mikulski M, Becam J, Lacassin F, Lefèvre P, Gourinat AC, Goarant C, D’Ortenzio E. 2013
PLoS Neglected Tropical Diseases 7:e1991. Texte intégral

Differential in vivo gene expression of major Leptospira proteins in resistant or susceptible animal models.
Matsui, M., Soupe M. E., Becam J., Goarant C. 2012
Applied and Environmental Microbiology 78(17):6372-6376. vers PubMed

Rodent abundance dynamics and leptospirosis carriage in an area of hyper-endemicity in New Caledonia.
Perez J, Brescia F, Becam J, Mauron C, Goarant C. 2011
PLoS Neglected Tropical Diseases 5(10):e1361. Texte intégral

Gene expression profiles of immune mediators and histopathological findings in animal models of leptospirosis : comparison between susceptible hamsters and resistant mice.
Matsui M, Rouleau V, Bruyère-Ostells L, Goarant C. 2011
Infection and Immunity 79(11):4480-4492. vers PubMed

Differential cytokine gene expression according to outcome in a hamster model of leptospirosis.
Vernel-Pauillac F, Goarant C 2010
PloS Neglected Tropical Diseases 2010; 4(1):e582. Texte intégral

Rapid Leptospira identification by direct sequencing of the diagnostic PCR products in New Caledonia.
Perez J, Goarant C. 2010
BMC Microbiology 10:325. Texte intégral

[Hospital based active surveillance of human leptospirosis in Cambodia.].
Berlioz-Arthaud A, Guillard B, Goarant C, Hem S. 2010
Bulletin de la Société de Pathologie Exotique 103(2):111-118. vers PubMed

Leptospira : the dawn of the molecular genetics era for an emerging zoonotic pathogen.
Ko AI, Goarant C, Picardeau M.  2009
Nature Reviews Microbiology 7(10):736-47. vers PubMed

Outbreak of leptospirosis in New Caledonia : diagnosis issues and burden of disease.
Goarant C, Laumond-Barny S, Perez J, Vernel-Pauillac F, Chanteau S, Guigon A.  2009
Tropical Medicine and International Health 14(8):926-9. vers PubMed

Bilan de cinq années de surveillance biologique de la leptospirose humaine en Nouvelle-Calédonie (2001-2005).
Berlioz-Arthaud A, Merien F, Baranton G.  2007
Bulletin de la Société de Pathologie Exotique 100: 133-138. vers PubMed

Proinflammatory and immunomodulatory cytokine mRNA time course profiles in hamsters infected with a virulent variant of Leptospira interrogans.
Vernel-Pauillac F, Merien F.  2006
Infection and Immunity 74(7):4172-9. Texte intégral

Application of multilocus variable-number tandem-repeat analysis for molecular typing of the agent of leptospirosis.
Salaün L, Mérien F, Gurianova S, Baranton G, Picardeau M. 2006.
Journal of Clinical Microbiology 44(11):3954-62.Texte intégral

A rapid and quantitative method for the detection of Leptospira species in human leptospirosis.
Merien F, Portnoi D, Bourhy P, Charavay F, Berlioz-Arthaud A, Baranton G. 2005
FEMS Microbiology Letters 249(1):139-47. vers PubMed